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LKB1/AMPK by regulating mTORC1, p53 and other important molecules control cellular processes, such as cell cycle checkpoint, apoptosis, autophagy and cell polarity. Dysregulation of LKB1/AMPK causes loss of these control points and thus leads to unrestrained growth. Only a few representative molecules that are directly relevant to growth control are listed here.
TZD: Thiazolidinedione.
