Table 1. Hemodynamics.
AS: Phenylephrine | AS: Dobutamine | 2-way ANOVA | |||||||
---|---|---|---|---|---|---|---|---|---|
FAST (n=6) | IL (n=6) | HIEG+IL (n=6) | FAST (n=4) | HIEG (n=4) | |||||
BL vs. AS | Intervention | Interaction | |||||||
HR bpm | BL | 96 ± 28 | 103 ± 17 | 125 ± 20* | 77 ± 15 | 92 ± 13 | P < 0.0001 | P = 0.06 | P < 0.001 |
AS | 92 ± 18* | 112 ± 18 | 134 ± 19 | 149 ± 29 | 134 ± 55 | ||||
SBP mm Hg | BL | 90 ± 13 | 79 ± 12 | 83 ± 11 | 101 ± 14 | 103 ± 21** | P < 0.0001 | P < 0.05 | NS |
AS | 136 ± 31 | 102 ± 24 | 112 ± 24 | 117 ± 6 | 142 ± 11** | ||||
DBP mm Hg | BL | 55 ± 8 | 49 ± 10 | 44 ± 10* | 62 ± 9 | 60 ± 15 | P < 0.0001 | NS | P < 0.05 |
AS | 85 ± 24 | 61 ± 17 | 63 ± 22 | 58 ± 9 | 77 ± 11 | ||||
RPP SBP*HR | BL | 8,601 ± 2,759 | 7,593 ± 1,744 | 10,461 ± 2,764 | 7,837 ± 2,669 | 9,201 ± 498 | P < 0.0001 | NS | NS |
AS | 11,798 ± 5,101 | 11,128 ± 2,052 | 14,590 ± 4,081 | 17,462 ± 4,299 | 18,685 ± 7,382 |
AS – adrenergic stimulation; BL – baseline; FAST – fasted; IL – Intralipid; HIEG – hyperinsulinemic-euglycemic clamp; HR - heart rate; SBP – systolic blood pressure; DBP – diastolic blood pressure; RPP - rate pressure product.
P < 0.05 vs. FAST in dobutamine study;
P < 0.05 vs. IL;
NS – not significant.