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. Author manuscript; available in PMC: 2010 Apr 14.
Published in final edited form as: Bioorg Med Chem Lett. 2008 Dec 30;19(4):1233–1235. doi: 10.1016/j.bmcl.2008.12.096

Scheme 1.

Scheme 1

Synthesis a furan-based nonactic acid analog 11. Reagents and conditions: a) nBuLi, -78 °C, THF then propylene oxide, 66 %; b) Ac2O, pyridine, THF, 79%; c) BEt3, Fe2(SO4)3, ethyl DL-2-iodopropionate, DMSO, 11%; d) 2.5 M LiOH, MeOH, THF, 81%.