Table 1. List of modules where miRNAs have been selected as high-scoring regulators.
Module ID | Number of genes in the module | GO categories enriched for the module (p<0.05) | Regulators | Score |
15 | 73 | None | MAFB | 3065 |
NFIB | 2774 | |||
MSRB2 | 713 | |||
IGFALS | 464 | |||
NR2C1 | 457 | |||
CCL23 | 392 | |||
MORF4L1 | 288 | |||
FOS | 249 | |||
let-7c | 231 | |||
miR-125b | 209 | |||
17 | 17 | Digestion | NFIB | 3785 |
Proteolysis | HEYL | 2361 | ||
Lipid catabolic process | PLA2G1B | 2164 | ||
miR-216 | 1085 | |||
CCRL2 | 780 | |||
MC5R | 327 | |||
TRAF1 | 285 | |||
CDX1 | 261 | |||
DLX2 | 254 | |||
E2F1 | 251 | |||
IFNGR1 | 250 | |||
CCR9 | 244 | |||
TACR3 | 215 | |||
18 | 6 | Immune response | HOXC5 | 1937 |
HMGA1 | 1007 | |||
miR-142-5p | 863 | |||
miR-142-3p | 709 | |||
HLA-DRB1 | 380 | |||
CCL5 | 241 | |||
AXL | 215 | |||
CXCL14 | 214 | |||
25 | 9 | None | miR-200a | 1786 |
PPP1R1B | 727 | |||
GPR30 | 512 | |||
PTGER3 | 456 | |||
ZNF157 | 320 | |||
GNB3 | 262 | |||
GNG5 | 209 | |||
29 | 4 | Actomyosin structure organization and biogenesis | PPP1R12B | 7346 |
Smooth muscle contraction | miR-133a | 1216 | ||
Smooth muscle fiber development | TSC22D1 | 1209 | ||
Elastic fiber assembly | ANGPTL2 | 353 | ||
Striated muscle development | miR-145 | 220 | ||
35 | 20 | None | NFATC1 | 2827 |
SH3BP1 | 2162 | |||
FMNL2 | 699 | |||
RASSF4 | 381 | |||
GNAQ | 290 | |||
CTNNBIP1 | 288 | |||
miR-181* | 249 | |||
94 | 3 | Folic acid metabolic process | miR-10a | 253 |
Regulation of Notch signaling pathway | ||||
Folic acid transport |
All regulators that are above cutoff are listed for each module, and ordered according to their decreasing score value. MicroRNA genes are highlighted in bold.