Table 1. Comparison of the cholesterol binding domains of selected CDC toxins.
ALO443GSGKDKTAHYSTVIPLPPNSKNIKIVARECTGLAWEWWRTIINEQNVPLTNE494 |
PFO401GNYQDKTAHYSTVIPLEANARNIRIKARECTGLAWEWWRDVISEYDVPLTNN452 |
LLO455ENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKN506 |
ALV432GNWRDRSAHFSTEIPLPPNAKNIRIFARECTGLAWEWWRTVVDEYNVPLASD483 |
SLO481NNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAWEWWRKVIDERDVKLSKE532 |
IVL454ENDKDKLAHFTTSIYLPGNARNINIHAKECTGLAWEWWRTVVDDRNLPLVKN505 |
PLY399RNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRK450 |
OxP-1 RECTGLAWEWWRTV |
Abbreviations: ALO, anthrolysin O, from Bacillus anthracis; PFO, perfringolysin O, from Clostridium perfringens; LLO, listeriolysin O, from Listeria monocytogenes; ALV, alveolysin, from Bacillus alvi; SLO, streptolysin O, from Group A streptococcus; IVL, ivanolysin from Listeria ivanovi; PLY, pneumolysin from S. pneumoniae; OxP-1, Oxpholipin-1 (this manuscript).