Figure 3.

Effects of POPs on insulin action in adipocytes shown as the ability of differentiated 3T3-L1 adipocytes to take up radioactive-labeled glucose in response to insulin measured after 48 hr exposure to several POP mixtures found in crude oil from farmed Atlantic salmon. (A) POP mixture, (B) PCDD mixture, (C) PCDF mixture, (D) non–ortho-substituted PCB mixture, (E) mono–ortho-substituted PCB mixture, (F) Pesticide mixture, (G) DDT mixture, or (H) PCB mixture. Concentrations of POP mixtures are shown according to the highest contaminant compound present in the mixture, as well as the World Health Organization (WHO) 2005 TEQ for dioxins and dioxin-like PCBs (Van den Berg et al. 2006). Glucose uptake was determined in eight parallel wells for each mixture and for each concentration. Data are expressed as relative glucose uptake and presented as mean ± SE.

*p < 0.05 compared with vehicle (dimethyl sulfoxide)-treated cells.