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. 2009 Nov 19;118(4):465–471. doi: 10.1289/ehp.0901321

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Schematic representation of the possible mechanisms behind the development of the insulin resistance syndrome induced by POP exposure. POPs may activate nuclear receptors including aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR), constitutive androstane receptor (CAR), or yet unknown receptors. POP exposure may induce the regulation of genes involved in the inflammatory pathway, mitochondrial function, lipid oxidation, and lipogenesis, thereby contributing to the development of the insulin resistance syndrome.