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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2009 Oct 13;66(1):141–150. doi: 10.1007/s00280-009-1144-0

Figure 5.

Figure 5

Induction of KLF4 gene expression by DIM-C-pPhC6H5 and the 5,5’-dihydroxy and 5,5'-dimethyl analogs in SW480 and HT-29 cells. Induction of KLF-4 (A) and inhibition by T007 (B). Cells were treated with different concentrations of DIM-C-pPhC6H5 and the 5,5’-dihydroxy and 5,5'-dimethyl analogs or T007 alone or in combination for 24 hr, and KLF4 mRNA levels were determined by real-time polymerase chain reaction as described in the Materials and Methods. Each experiment was replicated ( > 3X). T007 did not inhibit KLF4 mRNA induction by DIM-C-pPhC6H5 and the 5,5’-dihydroxy and 5,5'-dimethyl analogs.