Table 1.
Baseline Characteristics and Follow-up of Participants in the MOBILIZE Boston Study, by Classification of Low and High Medication Adherence
| Characteristic, n (%) unless otherwise specified | Low adherence, (N = 314) | High adherence, (N = 340) | p Value |
| Age* | 78 ± 5.3 | 79 ± 5.4 | .02 |
| Male | 116 (37) | 130 (38) | .73 |
| Race (white) | 231 (74) | 278 (82) | .01 |
| Consumes alcohol 3–4 days/week | 70(22) | 93 (27) | .14 |
| Greater than high school education | 1188 (61) | 234 (69) | .02 |
| Functional status | .09 | ||
| No difficulty with any of the five ADLs | 230 (73) | 268 (79) | |
| Difficulty or inability to perform one or more ADL | 84 (27) | 72 (21) | |
| Physical activity | |||
| PASE score† | 100.0 (53–138) | 95.7 (56–145) | .27 |
| Cognitive impairment‡ | 64 (20) | 58 (17) | .28 |
| Executive function | |||
| Trails B time (s)† | 120 (85–193) | 118 (81–185) | .20 |
| Poor visual acuity§ | 30 (10) | 19 (6) | .06 |
| Severe depression‖ | 73 (23) | 51 (15) | .01 |
| Co-morbidity index* | 3.3 ± 1.7 | 3.0 ± 1.5 | .02 |
| Urinary incontinence | 142 (45) | 122 (36) | .01 |
| Total number of medications | .02 | ||
| 1–4 medications | 96 (31) | 96 (28) | |
| 5–7 medications | 107 (34) | 150 (44) | |
| >7 medications | 111 (35) | 94 (28) | |
| Psychotropic medication use | 73 (23) | 70 (21) | .41 |
| Total number of falls | 627 | 425 | <.001 |
| Person-years of follow-up | 585 | 614 | .46 |
| Number of falls per subject | <.001 | ||
| 0 | 113 (36) | 165 (49) | |
| 1 | 62 (20) | 79 (23) | |
| ≥2 | 139 (44) | 96 (28) |
Notes: ADL = Activities of daily living; PASE = Physical Activity Scale for the Elderly.
*
Mean ± standard deviation.
†
Median (IQ range).
‡
Mini-Mental Status Examination score <24.
§
Defined as <40/100.
‖
Revised Center for Epidemiologic Studies Depression score <60.