Table 2.

Top 24 SNP Associations Ranked by p Value for Meta-analysis of Four Cohorts for Survival to Age 90 Years or Older (n = 1,836) Compared With Survival to Age 55–80 Years (n = 1,955)^* and Second Discovery Stage Meta-analysis Results

Hit Number	Marker Name	Chromosome	Position	Closest Reference Gene	Distance (bp) From Closest Gene or Function	Alleles					Study Effect Direction	Number of Supporting SNPs	Effective Sample Size (proportion of total)	Second Discovery Stage Meta-analysis–CHARGE Plus Leiden and Denmark Cohorts
						Minor	Major	MAF	OR	p Value				Study Effect Direction Leiden/Denmark	OR	p Value
1	rs4443878	1	238971041	RGS7	34,398	T	C	.04	0.41	1.3 × 10−6	−−−−	10	2,435	++	0.83	.068
2	rs9825185	3	196415923	C3orf21	Intron	C	A	.13	1.44	2.5 × 10−6	++++	24	0.64	−−	1.10	.045
3	rs954551	6	102886028	GRIK2	262,554	G	A	.25	0.77	5.3 × 10−6	−−−−	55	0.88	†	—	—
4	rs7624691	3	138345769	IL20RB	133,159	C	T	.43	0.80	8.8 × 10−6	−−−−	67	0.92	++	0.95	.092
5	rs10888267	1	246126046	OR2W3	Missense	C	T	.45	1.25	9.7 × 10−6	++++	2	0.92	†	—	—
6	rs9972933	17	28589381	ACCN1	Intron	T	C	.23	0.77	1.1 × 10−5	−−−−	30	0.91	+−	0.89	.003
7	rs2739532	4	190944424			C	G	.27	1.48	1.1 × 10−5	?+?+	9	0.99	‡	—	—
8	rs8029244	15	98826098	LASS3	Intron	A	G	.49	0.79	1.2 × 10−5	−−−−	108	0.37	+−	0.90	.002
9	rs16850255	1	175085164	PAPPA2	6,573	C	T	.21	0.75	1.2 × 10−5	−−−−	81	0.86	++	0.92	.041
10	rs1543505	14	22432468	REM2	5,739	G	A	.28	1.27	1.3 × 10−5	++++	23	0.83	−+	1.12	.001
11	rs7321904	13	80681190	SPRY2	868,103	T	C	.07	0.64	1.3 × 10−5	−−−−	40	0.93	++	0.92	.179
12	rs17401847	1	20111053	OTUD3	971	G	A	.15	1.38	1.4 × 10−5	++++	26	0.90	−+	1.12	.015
13	rs3124736	10	115487102	CASP7	6,450	A	G	.03	2.30	1.4 × 10−5	+++?	0	0.89	‡	—	—
14	rs690232	9	92422258	DIRAS2	Intron	A	G	.30	1.27	1.6 × 10−5	+++−	68	0.64	†	—	—
15	rs9664222	10	89328613	MINPP1	25,489	A	C	.21	0.77	1.6 × 10−5	−−−−	55	0.93	−−	0.82	6.77 × 10−7
16	rs11157721	14	49586464	LOC196913	33,655	T	C	.39	0.79	1.7 × 10−5	−−−−	53	0.86	+−	0.90	.002
17	rs4690810	4	166500130	SC4MOL	16,456	C	T	.35	0.79	1.9 × 10−5	−−−−	81	0.85	++	0.93	.044
18	rs11605096	11	113047320	TMPRSS5	16,162	A	C	.12	0.71	1.9 × 10−5	−−−−	94	0.93	†	—	—
19	rs16972414	18	35709920	PIK3C3	2,079,276	G	A	.30	0.79	2.0 × 10−5	−−−−	94	0.93	†	—	—
20	rs12935091	16	70082709	ZNF19	1,954	G	A	.07	0.62	2.0 × 10−5	−−−−	46	0.94	−+	0.80	.002
21	rs210332	14	53262222	BMP4	223,982	C	T	.19	1.33	2.3 × 10−5	++++	2	0.65	†	—	—
22	rs17369174	8	76128602	CRISPLD1	19,256	G	T	.10	0.69	2.3 × 10−5	−−−−	83	0.79	+−	0.86	.014
23	rs6721003	2	166931758	SCN7A	38,026	A	G	.45	1.23	2.4 × 10−5	++++	55	0.91	−+	1.09	.006
24	rs4734457	8	101573533	ANKRD46	28,644	A	C	.10	1.75	2.5 × 10−5	++++	0	0.99	+−	1.10	.098

Notes: p Values are for the inverse variance–weighted meta-analysis. Distances to genes are given in base pairs. Position is for NCBI Build 36. ORs are for each additional minor allele. Number of supporting SNPs: The number of SNPs within 500 kb of the top SNP that are in LD with the top SNP in the HapMap CEU release 22 (r² ≥ .10) and have association p < .05. For imputed and direction, study-specific information is presented in the order: Age, Gene/Environment Susceptibility-Reykjavik Study, Rotterdam Study, FHS, CHS, Leiden, and Denmark. Direction: + = minor allele increases odds of survival more than 90; − = minor allele decreases odds of survival; ? = not tested. CEU = Centre d'Etude du Polymorphisme Humain European Ancestry; CHARGE = Cohorts for Heart and Aging Research in Genomic Epidemiology; CHS = Cardiovascular Health Study; FHS = Framingham Heart Study; LD = linkage disequilibrium; MAF = minor allele frequency; OR = odds ratio; SNPs = single-nucleotide polymorphisms.

^*For information on all SNP associations with p < 10⁻⁴, see Supplementary Table 2.

^†Genotyping requested, not completed.

^‡Genotyping not requested.