TABLE 3.

Fatty acid composition of total serum lipids at baseline and at 6 mo by dose¹

Fatty acid and time	1 capsule (n = 12)	3 capsules (n = 12)	6 capsules (n = 12)	9 capsules (n = 12)
	% of total fatty acids	% of total fatty acids	% of total fatty acids	% of total fatty acids
14:0
0 mo	0.96 ± 0.44	0.89 ± 0.51	0.77 ± 0.34	0.72 ± 0.34
6 mo	0.94 ± 0.38	0.63 ± 0.39	0.71 ± 0.34	0.50 ± 0.19
16:0
0 mo	23.64 ± 3.26	22.79 ± 3.08	22.49 ± 1.74	22.58 ± 1.76
6 mo	24.18 ± 3.58	21.31 ± 2.92	22.18 ± 2.47	22.14 ± 1.71
16:1ω-7
0 mo	1.96 ± 0.87	1.78 ± 0.71	2.33 ± 2.79	1.44 ± 0.46
6 mo	1.91 ± 1.09	1.52 ± 0.71	1.13 ± 0.46	0.91 ± 0.22
18:0
0 mo	8.47 ± 0.86	9.33 ± 1.86	9.33 ± 1.77	9.33 ± 1.95
6 mo	8.56 ± 1.08	8.79 ± 1.31	10.14 ± 1.32	10.01 ± 1.40
18:1ω-9
0 mo	20.10 ± 2.96	18.53 ± 2.68	16.41 ± 4.80	17.76 ± 3.21
6 mo	18.18 ± 3.18	15.40 ± 2.76	14.13 ± 2.12	13.97 ± 2.14
18:1ω-7
0 mo	1.94 ± 0.37	2.10 ± 0.34	3.26 ± 4.52	1.94 ± 0.40
6 mo	1.64 ± 0.16	1.94 ± 0.36	1.70 ± 0.27	1.69 ± 0.36
LA
0 mo	27.26 ± 5.30	27.93 ± 4.43	28.85 ± 4.04	28.63 ± 3.61
6 mo	27.85 ± 6.49	29.32 ± 4.30	26.72 ± 4.22	26.95 ± 3.00
18:3ω-6
0 mo	0.50 ± 0.16	0.39 ± 0.18	0.44 ± 0.13	0.47 ± 0.18
6 mo	0.43 ± 0.18	0.38 ± 0.26	0.29 ± 0.13	0.26 ± 0.14
18:3ω-3
0 mo	0.65 ± 0.27	0.74 ± 0.21	0.57 ± 0.21	0.57 ± 0.15
6 mo	0.56 ± 0.18	0.68 ± 0.32	0.53 ± 0.22	0.50 ± 0.17
20:2ω-6
0 mo	0.29 ± 0.05	0.41 ± 0.39	0.26 ± 0.06	0.30 ± 0.04
6 mo	0.25 ± 0.08	0.43 ± 0.37	0.26 ± 0.16	0.24 ± 0.06§
20:3ω-6
0 mo	2.05 ± 0.42	2.04 ± 0.44	2.06 ± 0.44	2.02 ± 0.48
6 mo	1.77 ± 0.26	1.51 ± 0.33	1.35 ± 0.31	1.26 ± 0.46
20:4ω-3
0 mo	0.17 ± 0.14	0.16 ± 0.08	0.22 ± 0.15	0.13 ± 0.1
6 mo	0.17 ± 0.13	0.22 ± 0.24	0.18 ± 0.14	0.18 ± 0.1
AA
0 mo	7.72 ± 1.72	8.27 ± 2.25	7.89 ± 1.49	9.07 ± 2.93
6 mo	7.11 ± 1.64	7.04 ± 2.262	7.25 ± 2.102	6.88 ± 1.102
EPA
0 mo	0.63 ± 0.38	0.57 ± 0.26	0.96 ± 1.03	0.68 ± 0.40
6 mo	1.52 ± 0.46	2.75 ± 1.072	5.65 ± 1.942	5.98 ± 2.032
22:2ω-6
0 mo	0.14 ± 0.21	0.03 ± 0.08	0.02 ± 0.07	0.001 ± 0.002
6 mo	0.09 ± 0.14	0.03 ± 0.1	0.02 ± 0.03	0.03 ± 0.04
22:4ω-6
0 mo	0.28 ± 0.11	0.29 ± 0.13	0.26 ± 0.08	0.32 ± 0.16
6 mo	0.24 ± 0.10	0.16 ± 0.11	0.09 ± 0.08	0.18 ± 0.19
22:5ω-3
0 mo	0.68 ± 0.30	0.65 ± 0.29	0.69 ± 0.30	0.68 ± 0.28
6 mo	0.74 ± 0.27	1.01 ± 0.33	1.21 ± 0.33	1.26 ± 0.26
DHA
0 mo	1.59 ± 0.62	1.99 ± 0.84	2.20 ± 1.38	2.07 ± 0.77
6 mo	2.90 ± 0.722	4.23 ± 0.862	5.57 ± 1.432	6.26 ± 1.642
ω-3:ω-6
0 mo	0.10 ± 0.03	0.11 ± 0.04	0.12 ± 0.06	0.10 ± 0.03
6 mo	0.16 ± 0.03	0.23 ± 0.062	0.38 ± 0.122	0.40 ± 0.122

¹All values are means ± SDs. LA, linoleic acid; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; AA, arachidonic acid. A linear mixed-effects model was used to compare differences between 0 and 6 mo for DHA, EPA, AA, and LA and ω-3:ω-6 ratio. No significant differences between baseline and 6 mo were found for LA at all doses and for EPA and AA and ω-3:ω-6 ratio at 1 capsule/d. There was no evidence of a significant interaction between dose and time on the basis of current data for DHA, EPA, LA, and AA and ω-3:ω-6 ratio.

²Significantly different from 0 mo (baseline), P < 0.012 (Bonferroni adjusted).