TABLE 3.
Association of APOE ϵ4+ genotype and diet- and exercise-related changes at 6-wk follow-up (n = 272)1
| Health-behavior change | Unadjusted OR (95% CI) | P | Adjusted OR (95% CI)2 | P |
| Any dietary change | 1.98 (1.14, 3.45) | 0.01 | 2.32 (1.29, 4.36) | 0.01 |
| Diet | 1.37 (0.75, 2.50) | 0.31 | 1.56 (0.80, 3.02) | 0.19 |
| Exercise | 1.52 (0.82, 2.80) | 0.18 | 1.85 (0.96, 3.57) | 0.07 |
| Dietary supplements | 4.61 (2.29, 9.29) | <0.0001 | 4.75 (2.23, 10.10) | <0.0001 |
1
OR, odds ratio. Univariate and multivariate logistic regression analyses were used to identify diet- and exercise-related changes made 6 wk after genotype disclosure. For each health-behavior change, the reference genotype was ϵ4−.
2
Endpoints were adjusted for age, sex, race, randomization arm, baseline prevention, number of affected relatives, and education (<4 or ≥4 y of college).