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Effect of β-carbolines on cytochrome c release and caspase-3 activation. PC12 cells were treated with 500 µM SNAP in the presence of β-carbolines or R-(-)-deprenyl (each 25 µM) for 24 hours. Data are expressed as nanograms/ml for cytochrome c release (A) and units for caspase-3 activity (B). The values represent means±SEM of 4-6 replicate values in two separated experiments. †P<0.05, compared to control. *P<0.05, compared to SNAP alone.
