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Effect of β-carbolines and R-(-)-deprenyl on ROS formation and GSH depletion. PC12 cells were treated with 500 µM of SNAP in the presence of 5-100 µM β-carbolines (harmalol and harmine) or R-(-)-deprenyl for 24 hours. The values are expressed as arbitrary units of fluorescence for ROS formation (A) and nmol for GSH contents (B). Data represent means±SEM of 5-6 replicate values in two separated experiments. †P<0.05, compared to control. *P<0.05, compared to SNAP alone.
