Table 4. Statistical comparisons of each of the following structures: thalamus, hippocampus, amygdala, nucleus accumbens, caudate nucleus, globus pallidus and putamen, with no covariates.

Significant (p<0.05) effects are shown in bold.

F (df1,df2) p	Measure	Baseline	Longitudinal
		group effect	group effect	time effect	group–by–time interaction
Thalamus	Volume	2.79 (2,115) 0.066	2.2 (4,112) 0.074	14.55 (1,115) 0.0002	3.86 (1, 115) 0.052
	Shape	2.54 (15,102) 0.0031	2.97 (15,101) 0.0006	5.27 (15,101) <0.0001	1.91 (15,101) 0.031
Hippocampus	Volume	1.35 (2,113) 0.26	1.15 (4,110) 0.34	8.04 (1,113) 0.0054	1.25 (1,113) 0.27
	Shape	0.95 (15,100) 0.52	0.93 (15,99) 0.53	4.71 (15,99) <.0001	2.22 (15,99) 0.010
Amygdala	Volume	4.15 (2,113) 0.018	2.67 (4,110) 0.036	32.2 (1,113) <0.0001	0.18 (1,113) 0.68
	Shape	2.54 (15,100) 0.0031	2.49 (15,99) 0.0037	3.77 (15,99) <0.0001	0.47 (15,99) 0.95
Caudate Nucleus	Volume	1.39 (2,115) 0.25	2.1 (4,112) 0.086	2.14 (1,115) 0.15	5.23 (1,115) 0.024
	Shape	2 (15,102) 0.022	2.04 (15,101) 0.019	2.8 (15,101) 0.0011	1.78 (15,101) 0.047
Putamen	Volume	0.01 (2,115) 0.99	0.36 (4,112) 0.83	1.21 (1,115) 0.27	1.1 (1,115) 0.30
	Shape	2.14 (15,102) 0.013	2.16 (15,101) 0.013	4.09 (15,101) <0.0001	1.09 (15,101) 0.38
Nucleus Accumbens	Volume	1.67 (2,115) 0.19	1.55 (4,112) 0.19	0.1 (1,115) 0.76	2.74 (1,115) 0.10
	Shape	1.68 (15,102) 0.066	1.48 (15,101) 0.13	2.53 (15,101) 0.0032	2.23 (15,101) 0.0096
Globus Pallidus	Volume	0.02 (2,115) 0.98	0.23 (4,112) 0.92	2.3 (1,115) 0.13	0.79 (1,115) 0.37
	Shape	1.82 (15,102) 0.042	1.85 (15,101) 0.037	1.5 (15,101) 0.12	0.71 (15,101) 0.77