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. Author manuscript; available in PMC: 2011 Mar 5.
Published in final edited form as: Circ Res. 2009 Dec 31;106(4):739–747. doi: 10.1161/CIRCRESAHA.109.206763

Figure 7.

Figure 7

Ca2+ inactivation may silence LTCCs during depolarization of venous smooth muscle (A) Tracings of single LTCC currents in freshly isolated SMCs of rat MA revealed frequent openings in the cell-attached mode. (B) Under the same conditions, venous SMCs showed only rare openings, but activity was greatly increased after chelating intracellular Ca2+ with BAPTA-AM (C, 100 µmol/L). (c = closed state). (D) The open-state probability (NPO) was significantly higher in control MA compared to control MV and chelating intracellular Ca2+ with BAPTA-AM significantly increased MV NPO (n = 6–10). (E) The single channel conductance was not significantly different between MA and MV (n = 30–40 openings from 3 different cell isolations). * = significant difference from MA Control (p<0.05) (n = 30–40 openings from 3 different cell isolations). † = significantly different from MV Control (p<0.05).