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. Author manuscript; available in PMC: 2011 Apr 9.
Published in final edited form as: Mol Cell. 2010 Apr 9;38(1):101–113. doi: 10.1016/j.molcel.2010.03.009

Figure 6.

Figure 6

Implications of the TRAF1/2: cIAP1/2 interaction

(A) Comparison of the TRAF2: cIAP2 interaction with the dimeric XIAP BIR1: TAB1 interaction. The TAB1-interacting surface of XIAP BIR1 overlaps with the TRAF2-interacting surface of cIAP BIR1. The dimerization interface of XIAP BIR1 is opposite of the above interface.

(B) Comparison of the TRAF2: cIAP2 interaction with the XIAP BIR3: Smac peptide interaction. Smac peptide is bound to the opposite side of the TRAF2: cIAP interface.

(C) The heterotrimer of TRAF1 and TRAF2 in complex with cIAP2, showing the ubiquitination sites on TRAF1.