Table 1.
Characteristics and Disease History of Subjects
| Subject 1 | Subject 2 | |
|---|---|---|
| Gender | Female | Female |
| Age (years) | 35 | 60 |
| Duration of disease (years) | 4 | 8 |
| Rheumatoid factor | + | + |
| Prior DMARD and steroid use | MethylprednisoloneDiclofenacResochinMethotrexate | PrednisoloneMeloxicamMethotrexate |
| Therapy at time of study | NeurofenacMonoflamTramalNovalgin | PrednisoneTramalMobic |
| IL-1Ra productiona per 106 autologous synoviocytes per 48 hr (ng) | ||
| Before transduction | 0 | 0 |
| After transduction | 56 | 97 |
Abbreviation: DMARD; disease-modifying antirheumatic drug; IL-1Ra, interleukin-1 receptor antagonist.
a
IL-1Ra production was measured by ELISA of conditioned medium.