. Author manuscript; available in PMC: 2011 Apr 1.

Published in final edited form as: Cancer. 2010 Apr 1;116(7):1691–1698. doi: 10.1002/cncr.24913

Table 2.

Univariate Association of Covariates with Defective versus Intact MMR Status (N= 982)

Variable or Model	Odds Ratio (95% CI)¹	c-statistic²
Tumor Site (proximal vs. distal)	12.26 (6.82, 22.07)	0.764 (0.729)
Histologic Grade (poor/undifferentiated vs. well/moderate)	3.84 (2.65, 5.59)	0.682 (0.641)
Sex (male vs. female)	0.54 (0.38, 0.77)	0.618 (0.575)
Age ≥ 70	1.64 (1.13, 2.39)	0.602 (0.555)
LN metastasis (1–3 vs. 0) (> 3 vs. 0)	0.76 (0.46, 1.26) 0.61 (0.34, 1.11)	0.593 (0.568)
T-stage (_{3, 4 vs. 1, 2})	1.58 (0.84, 2.95)	0.585 (0.524)
Stage (II vs. III)	1.51 (0.96, 2.39)	0.582 (0.553)

logistic models adjusted for adjuvant study; c-statistic was unadjusted.

adjusted for adjuvant study (unadjusted in parenthesis).