Table 3.
Inbred strains with elevated ABR thresholds (dB SPL). A total of 326 mice from 19 strains with early onset hearing loss and 82 mice from 16 strains with late onset hearing loss were tested
Strain | Number mice | Age (weeks) | Clicks |
8 kHz |
16 kHz |
32 kHz |
||||
---|---|---|---|---|---|---|---|---|---|---|
mean | S.D. | mean | S.D. | mean | S.D. | mean | S.D. | |||
Normal grand means | 430 | 38 | 3 | 29 | 3 | 18 | 4 | 44 | 3 | |
a. Strains with early onset hearing loss (before 13 weeks of age) | ||||||||||
129/J | 5 | 9 | 52 | 8 | 47 | 8 | 33 | 12 | 69 | 7 |
129/J | 5 | 13 | 59 | 11 | 49 | 7 | 42 | 10 | 72 | 9 |
129/J | 12 | 28 | 87 | 15 | 65 | 15 | 76 | 13 | 87 | 11 |
129/ReJ | 12 | 9 | 52 | 9 | 45 | 8 | 33 | 10 | 62 | 10 |
129/ReJ | 5 | 12 | 62 | 6 | 54 | 11 | 37 | 8 | 73 | 9 |
129/ReJ | 5 | 23 | 81 | 7 | 70 | 5 | 65 | 6 | 94 | 7 |
129/SvJ | 4 | 9 | 53 | 9 | 55 | 12 | 41 | 5 | 68 | 12 |
129/SvJ | 5 | 13 | 46 | 4 | 36 | 4 | 21 | 4 | 55 | 5 |
129/SvJ | 6 | 45 | 100 | 13 | 81 | 13 | 77 | 13 | 102 | 11 |
A/J | 5 | 8 | 46 | 4 | 33 | 6 | 38 | 8 | 53 | 6 |
A/J | 5 | 10 | 48 | 8 | 30 | 5 | 59 | 7 | 49 | 11 |
A/J | 5 | 13 | 54 | 7 | 38 | 8 | 70 | 8 | 56 | 4 |
A/J | 6 | 30 | 73 | 10 | 64 | 14 | 76 | 10 | 89 | 14 |
A/J | 7 | 40 | 106 | 10 | 90 | 13 | 93 | 9 | 110 | 9 |
ALR/LtJ | 4 | 26 | 117 | 5 | 104 | 0 | 99 | 0 | 119 | 0 |
ALS/LtJ | 1 | 9 | 60 | 55 | 55 | 70 | ||||
BUB/BnJ | 6 | 3 | 93 | 5 | 69 | 9 | 60 | 8 | 74 | 19 |
BUB/BnJ | 8 | 8 | 102 | 14 | 83 | 17 | 79 | 17 | 101 | 14 |
BUB/BnJ | 5 | 13 | 101 | 4 | 86 | 7 | 78 | 8 | 103 | 9 |
BUB/BnJ | 5 | 20 | 117 | 4 | 102 | 4 | 97 | 4 | 117 | 4 |
C57BLKS/J | 7 | 11 | 46 | 9 | 41 | 14 | 36 | 15 | 61 | 16 |
C57BLKS/J | 4 | 15 | 41 | 5 | 33 | 6 | 18 | 3 | 55 | 4 |
C57BLKS/J | 6 | 45 | 67 | 7 | 52 | 14 | 78 | 6 | 79 | 17 |
C57BR/cdJ | 6 | 7 | 48 | 7 | 48 | 8 | 23 | 7 | 61 | 9 |
C57BR/cdJ | 8 | 20 | 62 | 19 | 61 | 18 | 43 | 24 | 82 | 18 |
C57BR/cdJ | 10 | 34 | 75 | 15 | 74 | 15 | 49 | 16 | 89 | 15 |
C57BR/cdJ | 8 | 68 | 88 | 12 | 76 | 15 | 61 | 15 | 97 | 9 |
C57L/J | 5 | 9 | 69 | 4 | 73 | 4 | 47 | 6 | 83 | 8 |
C57L/J | 6 | 32 | 88 | 8 | 78 | 8 | 58 | 8 | 101 | 12 |
C57L/J | 14 | 42 | 85 | 17 | 77 | 13 | 53 | 18 | 93 | 14 |
C57L/J | 6 | 50 | 73 | 8 | 69 | 10 | 40 | 8 | 93 | 5 |
C57L/J | 5 | 70 | 91 | 15 | 78 | 18 | 60 | 20 | 104 | 13 |
DBA/2J | 6 | 3 | 43 | 4 | 28 | 4 | 28 | 18 | 53 | 12 |
DBA/2J | 5 | 5 | 61 | 14 | 44 | 11 | 51 | 18 | 67 | 13 |
DBA/2J | 5 | 8 | 55 | 8 | 46 | 9 | 62 | 10 | 67 | 12 |
DBA/2J | 5 | 11 | 65 | 4 | 48 | 10 | 69 | 4 | 72 | 9 |
DBA/2J | 5 | 14 | 68 | 15 | 52 | 17 | 60 | 7 | 72 | 16 |
DBA/2J | 6 | 28 | 106 | 16 | 96 | 9 | 90 | 11 | 110 | 11 |
DBA/2J | 2 | 44 | 107 | 17 | 87 | 24 | 95 | 6 | 119 | 0 |
I/LnJ | 7 | 12 | 49 | 15 | 48 | 17 | 27 | 16 | 59 | 19 |
MA/MyJ | 5 | 6 | 36 | 2 | 27 | 6 | 32 | 19 | 52 | 22 |
MA/MyJ | 7 | 13 | 45 | 6 | 31 | 3 | 52 | 11 | 59 | 4 |
MA/MyJ | 5 | 42 | 95 | 32 | 80 | 27 | 79 | 14 | 103 | 22 |
NOD.B10-H2b | 13 | 10 | 96 | 20 | 91 | 12 | 90 | 11 | 111 | 14 |
NOD.NON-H2nb1 | 5 | 11 | 64 | 14 | 66 | 25 | 79 | 13 | 88 | 26 |
NOD.NON-Thy1a | 5 | 8 | 71 | 9 | 93 | 4 | 91 | 2 | 108 | 4 |
NOD/LtJ | 5 | 3 | 59 | 4 | 46 | 5 | 64 | 4 | 78 | 11 |
NOD/LtJ | 8 | 9 | 83 | 9 | 86 | 14 | 88 | 14 | 109 | 14 |
NOD/LtJ | 6 | 13 | 107 | 16 | 103 | 4 | 98 | 4 | 118 | 4 |
NOR/LtJ | 5 | 9 | 85 | 12 | 74 | 17 | 81 | 9 | 100 | 14 |
NOR/LtJ | 5 | 15 | 103 | 22 | 95 | 10 | 93 | 13 | 115 | 8 |
NOR/LtJ | 3 | 34 | 119 | 0 | 104 | 0 | 99 | 0 | 119 | 0 |
SKH2/J-hr | 5 | 10 | 89 | 25 | 67 | 22 | 69 | 22 | 90 | 26 |
SKH2/J-hr | 3 | 46 | 116 | 2 | 104 | 0 | 99 | 0 | 119 | 0 |
SKH2/J-hr | 4 | 63 | 117 | 2 | 99 | 6 | 99 | 0 | 117 | 5 |
Number of mice tested | 326 | |||||||||
b. Strains with late onset hearing loss (beyond 13 weeks of age) | ||||||||||
129/SvEMS−+Ter?/J | 8 | 35 | 53 | 18 | 54 | 12 | 26 | 15 | 67 | 13 |
A/WySnJ | 4 | 34 | 46 | 8 | 33 | 6 | 38 | 12 | 48 | 6 |
C3H/HeSnJ | 6 | 45 | 47 | 8 | 45 | 13 | 28 | 12 | 61 | 9 |
C57BL/6J | 7 | 100 | 106 | 11 | 84 | 10 | 78 | 16 | 105 | 9 |
C58/J | 3 | 30 | 62 | 3 | 50 | 5 | 43 | 3 | 72 | 8 |
CE/J | 6 | 50 | 62 | 10 | 44 | 7 | 37 | 9 | 63 | 8 |
DBA/1J | 5 | 48 | 57 | 4 | 40 | 6 | 42 | 17 | 59 | 7 |
DBA/1LacJ | 5 | 33 | 74 | 11 | 67 | 21 | 81 | 16 | 82 | 14 |
KK/H1J | 5 | 50 | 56 | 28 | 49 | 29 | 33 | 25 | 60 | 31 |
LG/J | 4 | 48 | 61 | 17 | 51 | 8 | 33 | 12 | 66 | 14 |
LP/J | 4 | 31 | 96 | 23 | 76 | 22 | 79 | 19 | 98 | 19 |
LP/J | 4 | 49 | 118 | 2 | 96 | 6 | 92 | 5 | 117 | 2 |
MRL/MpJ | 6 | 30 | 40 | 3 | 51 | 11 | 26 | 19 | 67 | 14 |
P/J | 5 | 19 | 54 | 22 | 46 | 20 | 23 | 21 | 60 | 22 |
SENCARA/PtJ | 3 | 44 | 53 | 15 | 40 | 23 | 55 | 10 | 73 | 28 |
SENCARB/PtJ | 5 | 39 | 55 | 23 | 42 | 25 | 36 | 20 | 64 | 23 |
YBR/Ei | 2 | 60 | 58 | 25 | 58 | 25 | 38 | 25 | 68 | 25 |
Number of mice tested | 82 |