Table 1.

Impact of patient age on outcomes following esophageal resection for cancer, selected recent studies

Author	Study Period Data Source	Age cohorts	Study Population	Operative mortality (%)	Five-year survival	Overall survival Adjusted hazard ratio	P
Bailey et al [8] (2003)	1991–2000 VA-NSQIP	continuum	1777 (1509 cancer)	9.8		1.05/year	0.0001
Rouvelas et al [9] (2005)	1987–2000 Cancer Registry, Sweden	<55	104		27.4	1.00 (reference)
		55–65	218		26.0	1.08 (0.82–1.42)	NS
		66–75	302		25.0	1.01 (0.84–1.41)	NS
		>75	140		22.8	1.28 (0.96–1.72)	NS
Cronin-Fenton et al. [6] (2007)	1994–2001 Cancer Registry, Ireland	<70	No Surgery: 1705			1.00 (reference)	0.99
		70+				1.00 (0.89–1.12)
		<70	Resection: 927			1.00 (reference)	<0.001
		70+				1.52 (1.28–1.80)
Finlayson et al. [17] (2007)	1994–2003 NIS	65–69	9662	6.7
		70–79	15145	9.3
		80+	3150	15.5			<0.0001
	1992–2001 SEER-Medicare	65–69	75		31.4
		70–79	123		27.9
		80+	18		17.6		0.02
Poon et al. [19] (1998)	1982–1996 Clinical database	<70	570	3.0	35.0		<0.02/<0.01
		70+	167	7.2	26.0
Alexiou et al.[34] (1998)	1987–1997 Clinical database	<70	337	4.7	25.1		NS
		70–79	150	6.7	21.2
		80–86	36	5.6	19.8
Abunasra et al. [21] (2005)	1990–2003 Clinical database	<59.5	193	2.1		1.0 (reference)	0.009
		59.5–67.8	193	3.6		2.06 (0.52–8.22)
		67.9–73.2	194	4.1		1.55 (0.36–6.72)
		>73.2	193	9.3		4.87 (1.35–17.55)
Moskovitz et al. [22] (2006)	1996–2005 Clinical database	<50	107	1.9		1.0 (reference)
		50–59	228	4.8
		60–70	285	5.6
		70–79	207	7.3
		80+	31	19.4		3.9 (1.5–10.6)	<0.01
					Median survival (months):
		50–75			46.7
		75–79			29.1
		80+			16.8		0.01
					Five-year survival (%)
Current report (2009)	1993–2008 Clinical database	continuum	1251	2.6	39.7	1.022/year	<0.0001
		<55	241	0.8	59 (95% CI: 41, 55)
		55–64	390	3.3	42 (36, 48)
		65–74	418	2.2	38 (33, 43)
		>=75	202	4.0	28 (21, 35)

Abbreviations: SEER, Surveillance, Epidemiology, and End Results; NIS, Nationwide Inpatient Sample; VA-NSQIP, Department of Veterans’ Administration National Surgical Quality Improvement Program; NS, no statistically significant difference; N/A, not available