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. 2010 Apr 15;6(4):e1000842. doi: 10.1371/journal.ppat.1000842

Figure 4. Monocyte subsets leave the bone marrow at different rates that are accelerated in animals that develop SIVE.

Figure 4

BrdU was injected four times over the course of the study. Red = pre-infection (days −10 days post infection (dpi)), Blue = peak infection (7 dpi), Green = “asymptomatic” period (26 dpi) and Black = 88 dpi (slow progressors = A–B) or necropsy (rapid progressors = C–D). BrdU injections were given at 24hrs before necropsy. The percentage of BrdU+ monocytes in each subset was determined 24hr and 48hr and either 96 or 120 hrs after BrdU injection (Time: 0 hr). (A–B) Dots represent the averages of the percentage of BrdU+ cells in the subsets of slow progressors that remained asymptomatic throughout the period examined. A. There is no change in the percentage of BrdU+ CD14+CD16− cells between pre- and post-infection time points. B. There is a slight increase in the percentage of BrdU+ CD14+CD16+cells after infection that is apparent at 48hrs. (C–D) Dots are averages from two rapid progressors (244-96 and 55-05). The percentage of BrdU+ monocytes was only examined 24hrs after BrdU pulse for animals, DB79 and CM07. C. The difference in the percentage of BrdU+CD14+CD16− cells between pre- and post-infection is apparent at 24hrs. D. The difference in the percentage of BrdU+ CD14+CD16+cells between pre- and post-infection occurs at 48hrs. The error in all graphs is the standard error of the mean.