Table 1. Comparison with other methods on independent test set.

Method	Sensitivity	Specificity	Accuracy
geno2pheno	0.31	0.98	0.70
wetcat	0.63	0.98	0.83
two-levela	0.68	0.98	0.86
11/25	0.71	0.95	0.85
two-levelb	0.73	0.95	0.86
11/24/25	0.75	0.83	0.80
two-levelc	0.81	0.83	0.82

Performance of several methods on the same test set of 74 sequences with experimentally determined tropism. “Two-level” refers to the method described in this paper which is used at three different specificities, (a) at specificity of geno2pheno and wetcat, (b) at specificity of 11/25 rule, (c) at specificity of 11/24/25 rule.