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. 2010 Apr 15;6(4):e1000745. doi: 10.1371/journal.pcbi.1000745

Figure 1. A multi-variant viral dynamic model to quantify response to telaprevir treatment.

Figure 1

Panel a, Superset of HCV genotype 1a variants uncovered in subjects dosed with telaprevir. Each node represents a variant of which the amino acid mutation is printed. Only variants detected in ≥5 subjects are shown. Variants were within 2 nucleotide changes from wild-type HCV. Panel b, Schematic of the model. Panels c and d, correspondence between data and best-fit model for Subject 1. Diamonds, data; solid line, best-fit model; dashed lines, predicted variant contribution to the overall plasma HCV RNA; circles, HCV RNA levels of variants.