Fig 4.
Time course of the healing response for expanded polytetrafluoroethylene (ePTFE) at (A) 4 weeks, (B) 8 weeks, and (C) 12 weeks, and (D) polyester urethane urea (PEUU) at 4 weeks, (E) 8 weeks, and (F) 12 weeks, with hematoxylin and eosin staining (scale bars, 100 μm). The right ventricular cavity is to the left or lower left for all images. (A–C) No cellular ingrowth was observed with ePTFE, where the foreign body response was most exuberant with surface macrophages at 4 weeks, decreasing to thin fibrous tissue at 12 weeks. (D–F) PEUU scaffolds experienced cellular ingrowth and macrophage activity consistent with cellular infiltration and material degradation. (F) At 12 weeks the PEUU scaffolds were almost completely absorbed with microvasculature apparent on the endocardial side.