Table 1. Amplification of fosfomycin resistant mutants in mice treated with the antibiotic.
Strains | FosR mutant/total cfu (treated mice) | FosR mutant/total cfu (untreated mice) | Fold increase in Fos-R |
PA14 WT | 9.8×105 | 1.58×106 | 61.98 |
mutS::MAR2xT7 | 1.70×101 | 2.54×104 | 666.76 |
Fold increase values were calculated as the ratio between the median of the proportion of Fos-R mutants/total bacterial counts (figure 2B) of treated and untreated mice.