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. Author manuscript; available in PMC: 2011 Apr 22.
Published in final edited form as: J Med Chem. 2010 Apr 22;53(8):3013–3027. doi: 10.1021/jm9012938

Figure 5.

Figure 5

Radial phylogenetic tree of currently known KPC enzymes. Amino acid sequences of KPC enzymes including the leader sequence were retrieved from GenBank at http://www.ncbi.nlm.nih.gov/and aligned using Clustal X Version 2.0.9129 using default parameters. The phylogenetic tree was visualized using TreeView.130 The bar at the lower left corner gives a measure for amino acid sequence diversity. For instance, two enzymes differing by only one of 293 amino acid residues share 99.66% sequence identity and differ by 0.34% (0.0034). The KPC-9 sequence was missing five and four residues at the N- and C-termini, respectively. Since these residues are 100% conserved in the other enzymes, we added the missing residues accordingly. For more details see Supporting Information S2-S3.