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. Author manuscript; available in PMC: 2010 Oct 15.
Published in final edited form as: Nature. 2010 Mar 21;464(7291):1067–1070. doi: 10.1038/nature08956

Figure 2.

Figure 2

RRM2 mRNA and protein expression in tumor tissue. (a). qRT-PCR analysis of RRM2 mRNA levels in samples from patients A and B before and after dosing. RRM2 mRNA levels are normalized to TBP mRNA levels. Results are presented as percentage of the pre-dosing RRM2/TBP mRNA levels for each patient. (b). qRT-PCR and Western blot analysis of RRM2 protein expression from patient samples C2pre and C2post. Bar graph is average volume of Western blot bands from two independent experiments; one representative blot is pictured. Archived samples are indicated by (*); samples obtained during the trial are indicated by (¶).