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. Author manuscript; available in PMC: 2010 Oct 15.
Published in final edited form as: Nature. 2010 Mar 21;464(7291):1067–1070. doi: 10.1038/nature08956

Figure 3.

Figure 3

Ribonucleotide reductase (RRM2) and tranferrin receptor (TfR) protein expression in C1pre and C1post samples. Photomicrographs of malignant melanoma belonging to a, b, c, pre-treatment and d, e, f post-treatment samples. Protein expression is represented as brick-red (Nova Red) chromagen staining in immunohistochemically-treated slides (a, d: RRM2; b, e:TfR). c, f, The same tissues are stained with Hematoxylin and Eosin (H&E). d, e, f, Brown, diffuse, finely granular color seen in these images is the endogenous pigment of this lightly melanized tumor. Photomicrographs were captured using a 40× objective.