Table 3.

Allele and genotype frequencies of SNPs in ADPRT1, AKR1B1, RAGE, GFPT2, PAI and their association status with diabetic CRI, and the power of sample size to detect association at 5% significance level.

SNPs	Allele frequency		Genotype frequency		Association		Power (G %)
	DM	CRI	DM	CRI	Allele	Genotype
	(n = 225) (n = 196)		(n = 225)	(n = 196)	(df = 1)	(df = 2)
ADPRT1 T>C	T = 0.91 C = 0.09	T = 0.925 C = 0.075	TT = 0.87 TC = 0.12 CC = 0.01	TT = 0.83 TC = 0.16 CC = 0.01	χ2 = 0.21; P = 0.64, P* = 0.13	χ2 = 1.61; P = 0.45; P* = 0.11	12
ADPRT1 A>G	A = 0.91 G = 0.09	A = 0.92 G = 0.08	AA = 0.83 AG = 0.17 GG = 0.00	AA = 0.84 AG = 0.14 GG = 0.02	χ2 = 0.07; P = 0.79; P* = 0.13	χ2 = 3.3; P = 0.19; P* = 0.14	8
AKR1B1 G>C	G = 0.93 C = 0.07	G = 0.93 C = 0.07	GG = 0.86 GC = 0.14 CC = 0.00	GG = 0.89 GC = 0.11 CC = 0.00	χ2 = 0.88; P = 0.35; P* = 0.15	χ2 = 0.94; P = 0.33 (df = 1); P* = 0.14	0
RAGE -429T>C	T = 0.87 C = 0.13	T = 0.88 C = 0.12	TT = 0.77 TC = 0.22 CC = 0.01	TT = 0.81 TC = 0.14 CC = 0.05	χ2 = 0.04; P = 0.84; P* = 0.11	χ2 = 8.68; P = 0.013; P* = 0.015 OR = 9.03, 95% CI = (1.09<OR<74.26)	7
RAGE 63 bp ins/del	Ins = 0.96 Del = 0.04	Ins = 0.97 Del = 0.03	Ins/Ins = 0.95 Ins/Del = 0.05 Del/Del = 0.00	Ins/Ins = 0.91 Ins/Del = 0.09 Del/Del = 0.00	χ2 = 0.26; P = 0.60; P* = 0.15	P* = 0.06	12
GFPT2 C>T	C = 0.78 T = 0.22	C = 0.72 T = 0.28	CC = 0.50 CT = 0.45 TT = 0.05	CC = 0.60 CT = 0.37 TT = 0.03	χ2 = 3.92; P = 0.047; P* = 0.03 OR = 1.38, 95% CI = (1.02<OR<1.98)	χ2 = 4.5; P = 0.11; P* = 0.04	51
PAI-1 4G/5G (del/ins)	4G = 0.52 5G = 0.48	4G = 0.49 5G = 0.51	4G4G = 0.23 4G5G = 0.52 5G5G = 0.25	4G4G = 0.29 4G5G = 0.46 5G5G = 0.25	χ2 = 0.84; P = 0.36; P* = 0.06	χ2 = 2.5; P* = 0.29	14

P:P value for Pearson's chi-square test

P*: Fisher's exact P value.