Table 3.
Assumption about SCID sensitivity & specificity | Estimated true prevalence (95% CI) |
---|---|
Assuming no error in SCID | |
100% & 100% | 21% (19-23%) |
Using latent class analysis estimates | |
73% & 98% | 27% (24-29%) |
Varying sensitivity | |
89% & 98% | 22% (19-24%) |
56% & 98% | 35% (32-38%) |
Varying specificity | |
73% & 96% | 25% (22-27%) |
73% & 100% | 29% (26-31%) |
Monte Carlo simulation: Simultaneously considering range of possible values for sensitivity and specificity | |
(56-89%) & (96-100%) | 27% (22-33%)* |
95% simulation interval incorporates both uncertainty associated with random sampling error (as with a standard confidence interval) as well as uncertainty associated with the unknown values of SCID sensitivity and specificity.