Figure 2.

ROCKII^−/− developmental abnormalities. A, ROCKII^−/− pups are frequently born with forepaw and hindpaw digit malformations. B, The number of basal and apical dendrite branchpoints in ROCKII^+/+ and ROCKII^−/− adult CA1 hippocampal neurons were compared by Golgi staining. C, ROCKII^−/− adult mice exhibit a significantly greater number of branchpoints in their basal dendrites compared with ROCKII^+/+ littermates. D, E, ROCKII^−/− mice also display an increased number of basal dendrite intersections and dendrite length. All data are mean ± SEM, one-way ANOVA, p < 0.05.