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. 2009 Oct 28;29(43):13494–13502. doi: 10.1523/JNEUROSCI.2243-09.2009

Figure 4.

Figure 4.

BDNF injection into the DLS decreases ethanol self-administration by inducing an early termination of the drinking episode. Rats were microinjected with PBS or BDNF into the DLS 10 min (0.75 μg/μl/side over 2 min) or 3 h (0.08, 0.25, and 0.75 μg/μl/side over 2 min) before the beginning of the self-administration session. a, BDNF injected into the DLS dose-dependently decreases ethanol self-administration only when injected 3 h before the beginning of the session. Data are expressed as mean ± SEM number of presses. n = 8; **p < 0.01, ***p < 0.001 versus PBS group. b, Data are presented as mean ± SEM ethanol consumed in grams per kilogram. n = 8; *p < 0.05, **p < 0.01. c, BDNF induces an early termination of the drinking episode. Results are expressed as the mean ± SEM time of the last press in minutes. PBS and BDNF 0.08 μg/μl: n = 8; BDNF 0.25 μg/μl: n = 7; BDNF 0.75 μg/μl: n = 4; *p < 0.05. d, BDNF injection into the DLS does not alter sucrose self-administration. BDNF was injected into the DLS 3 h before the session of rats trained to self-administer sucrose for at least 2 months. The data are represented as mean ± SEM number of presses. n = 12.