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. Author manuscript; available in PMC: 2011 Apr 7.
Published in final edited form as: Cell Metab. 2010 Apr 7;11(4):298–310. doi: 10.1016/j.cmet.2010.03.006

Figure 4. Insulin secretion profiles in neuroD β-CKO islets.

Figure 4

(A) Isolated islets from control and neuroD β-CKO mice treated with different insulin secretagogues (2.8mM glucose, 16.7mM glucose, 20mM leucine, 30mM KCl, 50uM glipizide and 10 mM methyl pyruvate). Secreted insulin was normalized to total insulin in the islets (n= 6–10 per genotype). (B) Quantitative RT-PCR of Kir6.2, Sur1, piccolo and Noc2 mRNA in control and neuroD β-CKO islets. The data were normalized to β-actin mRNA (n=3–8 per genotype). (C) Respiration rate of control and neuroD β-CKO mice islets incubated with glucose and oligomycin (OM) (n=6–17 per genotype). * P≤0.05, ** P≤0.01 and *** P≤0.001.