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Administration of O-1966 reduces CD11b and ICAM-1 expression during cerebral ischemic/reperfusion injury. Expression of CD11b and ICAM-1 was determined by immunohistochemistry on brain slices obtained 24 h after ischemia. Four treatment groups were compared: vehicle treated, O-1966 administered prior to MCAO, O-1966 administered 1 h after occlusion, and O-1966 administered 3 h after occlusion
