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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Future Microbiol. 2010 Mar;5:431–453. doi: 10.2217/fmb.10.4

Figure 1. Ribbon diagram of Shiga toxin.

Figure 1

The enzymatic A-subunit (yellow) noncovalently associates with a pentameric ring of receptor-binding B-subunits. Following toxin internalization and proteolysis of the A-subunit by furin or calpain, a disulphide bond between C242 and C261 links the A1- and A2-fragments. Reproduced with permission from [3].