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Gene-by-lifestyle interactions in diabetes prevention studies
| Gene | Association | Risk reduction | Source |
|---|---|---|---|
| TCF7L2 | type 2 diabetes | 66% | DPP [24] |
| ENPP1 | type 2 diabetes | 55% | DPP [25] |
| TNF-α (−308A allele vs. G308G genotype) | type 2 diabetes | − | FDPS [23] |
| PPARG (Pro12A1a genotype) | obesity | 20% | DPP [28, 29] |
TNF-α polymorphism predicted diabetes in the lifestyle arm only. PPARG = Peroxisome proliferator-activated receptor-γ.
