Table 1. Allele Frequencies for ChAT SNPs and Association with Smoking Cessation.
| dbSNP ID (alleles)a | Hap block | Position | SNP location | MAF | MAF abstinent | MAF relapsed | ORb (95% CI) | p-Value (per allele) |
|---|---|---|---|---|---|---|---|---|
| rs11101179 (G/A) | 1 | 50480897 | 5' near gene | 0.29 | 0.3 | 0.29 | 1.05 (0.77, 1.43) | 0.75 |
| rs885834 (G/A) | 1 | 50485518 | 5' near gene | 0.41 | 0.44 | 0.39 | 1.25 (0.94, 1.43) | 0.12 |
| rs1880676 (A/G) | 2 | 50494123 | Intron | 0.34 | 0.39 | 0.33 | 1.34 (0.96, 1.87) | 0.08 |
| rs3810950 (A/G) | 2 | 50494625 | Exon | 0.26 | 0.28 | 0.25 | 1.19 (0.86, 1.66) | 0.29 |
| rs7091005 (A/G) | 50496169 | Intron | <0.1 | 0.08 | 0.07 | 1.23 (0.7, 2.14) | 0.47 | |
| rs10082479 (A/T) | 50499225 | Intron | 0.1 | 0.09 | 0.11 | 0.96 (0.65, 1.41) | 0.61 | |
| rs868750 (A/G) | 3 | 50503845 | Intron | 0.17 | 0.17 | 0.17 | 0.96 (0.65, 1.41) | 0.83 |
| rs4838392 (G/A) | 3 | 50504984 | Intron | 0.37 | 0.4 | 0.36 | 1.2 (0.88, 1.63) | 0.25 |
| rs2177370 (G/A) | 50508880 | Intron | 0.39 | 0.38 | 0.4 | 0.92 (0.68, 1.23) | 0.56 | |
| rs3793790 (G/A) | 50510742 | Intron | 0.33 | 0.35 | 0.33 | 1.11 (0.82, 1.51) | 0.49 | |
| rs3793791 (G/A) | 50511710 | Intron | <0.1 | 0.06 | 0.08 | 0.68 (0.4, 1.17) | 0.16 | |
| rs1917818 (C/A) | 4 | 50519348 | Intron | 0.39 | 0.43 | 0.37 | 1.3 (0.98, 1.7) | 0.072 |
| rs3793792 (A/G) | 4 | 50520169 | Intron | 0.39 | 0.43 | 0.38 | 1.29 (0.97, 1.7) | 0.08 |
| rs7903612 (G/C) | 4 | 50522533 | Intron | 0.32 | 0.3 | 0.32 | 0.9 (0.65, 1.23) | 0.49 |
| rs8178991 (A/G) | 4 | 50524643 | Exon | 0.03 | 0.03 | 0.02 | 1.3 (0.53, 3.15) | 0.57 |
| rs7094248 (C/G) | 4 | 50525374 | Intron | 0.50 | 0.54 | 0.48 | 1.32 (0.99, 1.75) | 0.06 |
| rs1917813 (G/A) | 5 | 50527841 | Intron | 0.48 | 0.52 | 0.46 | 1.27 (0.95, 1.68) | 0.1 |
| rs6537545 (G/A) | 5 | 50529255 | Intron | 0.47 | 0.51 | 0.46 | 1.23 (0.93, 1.64) | 0.15 |
| rs4838547 (G/A) | 6 | 50532410 | Intron | 0.44 | 0.5 | 0.42 | 1.53 (1.14, 2.04) | 0.004 |
| rs6537546 (T/A) | 6 | 50534049 | Intron | 0.09 | 0.06 | 0.11 | 0.60 (0.35, 1.03) | 0.06 |
| rs1917810 (G/A) | 6 | 50540077 | Intron | 0.44 | 0.5 | 0.42 | 1.53 (1.14, 2.04) | 0.004 |
| rs11101202(G/C) | 6 | 50542408 | Intron | 0.43 | 0.5 | 0.41 | 1.51 (1.13, 2.02) | 0.005 |
| rs867687(G/A) | 6 | 50547271 | 3'flanking | 0.22 | 0.19 | 0.23 | 0.76 (0.52, 1.1) | 0.14 |
Abbreviation: MAF, minor allele frequency.
a
The minor allele is bolded for each SNP.
b
Odds ratio for the minor allele adjusting for age, sex, and nicotine dependence score assuming an additive model (SNPs with p<0.05 are in bold). The direction of association can be determined based on the MAF in the abstinent and relapsed groups.