Immunohistochemical localization of brevican (rb18 monoclonal), the proteolytically cleaved fragments of brevican (rabbit polyclonal against the ADAMTS-derived fragment, anti-EAMESE; MMP-derived fragment, anti-SAHPSA; and Aβ plaques (95-2-5 rabbit polyclonal) in APPsw transgenic mice (representative from n = 6 APPsw mice). Epifluorescent micrographs of brevican immunoreactivity (A, H, K), anti-EAMESE immunoreactivity (D, G), anti-SAHPSA immunoreactivity (J) and Aβ (B, E) in fixed frontal/parietal cortical sections. Merged composites (C, F, I & L). All images captured at 200x magnification.