Table 1.

Quantitation of immunoreactivity of brevican isoforms in brain regions of APPsw transgenic (+) mice and non- transgenic littermates (expressed as arbitrary densitometric units).

		G1 brevican isoforms			ADAMTS-derived fragment	MMP-derived fragment
brain region	Tg	> 145 kD	145 kD	55 kD	EAMESE	SAHPSA
Frontal cortex	nt	28.25 ± 3.20	5.93 ± 0.43	1.87 ± 0.62	0.85 ± 0.16	0.18 ± 0.13
	APPsw	17.39 ± 2.21 *	7.85 ± 0.86*	1.62 ± 0.55	1 06 ± 0.14	0.08 ± 0.05
Temporal lobe	nt	25.05 ± 2.13	2.50 ± 0.03	3 18 ± 0.56	0.93 ± 0.28	0.59 ± 0.15
	APPsw	17.16 ± 2.40*	6.31 ± 0.44*	1.35 ± 0.26*	1.17 ± 0.39	0.33 ± 0.12
Cerebellum	nt	11.29 ± 1.08	2.98 ± 0.23	4.53 ± 0.44	1.22 ± 0.03	0.93 ± 0.05
	APPsw	8.54 ± 0.72*	6.85 ± 0.28*	2.37 ± 0.23*	1.41 ± 0.20	0.43 ± 0.12*
Hypothalamus	nt	11.90 ± 1.19	2.37 ± 0.56	1.35 ± 0.19	3.67 ± 0.31	0.68 ± 0.21
	APPsw	7.99 ± 1.36*	4.98 ± 0.74*	0.79 ± 0.11 *	3.18 ± 0.23	0.83 ± 0.30
Brain stem	nt	9.64 ± 2.25	1.90 ± 0.51	5.28 ± 0.72	2.31 ± 0.31	0.79 ± 0.26
	APPsw	7.31 ± 1.60	4.73 ± 0.83*	5.72 ± 0.81	2.29 ± 0.24	0.73 ± 0.26

^*indicates significantly different from non-transgenic