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Biological relationships among interleukin (IL)-6, C-reactive protein (CRP), and fibrinogen. Serum IL-6 has a number of biological sources, most notably adipocytes, which account for as much as 30% of circulating IL-6 levels (71) and immunocompetent cells. CRP and fibrinogen are principally synthesized in and released from the liver (72,73), and IL-6 is one of the most potent stimulators of their production.
