Figure 4.

Upon in vivo differentiation, the CSES lines generate teratomas. Upon in vivo differentiation into teratomas, the CSES cell lines differentiate into a variety of structures and comprised of heterogeneous cell types; shown are 4-μm sections of teratomas stained with hematoxylin and eosin. In all cell lines, we have seen presentation of structures from the three embryonic germ layers. Shown are variety of structures and cell types including neural rosettes, gut-like structures, cartilage, connective tissue, adipose, and muscle cells. Scale bar is 100 μm.