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. 2010 Jan 14;21(5):729–736. doi: 10.1007/s10552-010-9501-1

Table 1.

Summary results of semi-structured interviews and experts’ recommendations

Discussion topic Issues/salient comments Suggestions
What are key issues in PC research?

Late diagnosis leads to poor outcomes

Few effective treatments available

Delays in drug development pipeline

Absence of large, long-term studies

Limited understanding of the genetic basis of PC

Lack of screening techniques for familial PC

Develop better imaging technologies

Improve screening technologies

Focus on drug discovery

Individualised PC therapy

Pain management in advanced disease

More research on causes of cancer cachexia

Where is the next major breakthrough in PC research likely to come from?

A blood test for earlier detection

Ability to detect small volume/pre-malignant disease

Treatments based on tumour biology

The genome sequencing project

Gene discovery in familial PC syndromes

Better understanding of tumour biology

Developing small molecule inhibitors in PC

Identifying genes that can be targeted in therapy

New animal models for PC

Barriers to progress in PC research—how can they be addressed?

Limited research funding disadvantages small research groups and reduces long-term researcher commitments Relatively low numbers of PC cases

Lack of good disease models

Limited support from industry for PC clinical trials

Limited opportunities for collaboration between disciplines, the public and private sectors, different countries

Encourage funding of large, long-term studies

Broaden research collaborations

Develop clinico-pathological databases

Increase opportunities for participation in clinical trials

Collect more and better epidemiological data

Separate PC from other GI cancer trials

Where are Australian researchers most likely to make significant contributions to PC research Australia has well-annotated tissue and blood samples and a strong epidemiology record Australia can play a key role in developing databases and networks to increase research collaborations