Table 2.
Results of cross-reactivity testing.
| Compound | Closest similarity to target compounds (MDL, FCFP_6)1 | Cross-reactivity positives1 |
|---|---|---|
| Acetaminophen | AMPH 0.310, 0.132 | None |
| Atropine | OPI 0.581, 0.159 | OPI 500,000 ng/mL2,4 |
| Azithromycin | PROP 0.532, 0.121 | None |
| Buspirone | BENZO 0.522, 0.088 | None |
| Caffeine | BENZO 0.524, 0.082 | None |
| Carbamazepine | TCA 0.460, 0.306 | None |
| Carisoprodol | BARB 0.508, 0.184 | None |
| Cetirizine | TCA 0.429, 0.120 | TCA 250,000 ng/mL3 |
| Chlorambucil | TCA 0.442, 0.177 | None |
| Chloroquine | TCA 0.686, 0.060 | None |
| Chlorzoxazone | BARB 0.508, 0.184 | None |
| Citalopram | PROP 0.534, 0.107 | TCA 500,000 ng/mL3,4 |
| Citalopram metabolite (N-desmethyl) | TCA 0.517, 0.176 | None |
| Clotrimazole | BENZO 0.473, 0.171 | None |
| Clozapine | BENZO 0.650, 0.174 | None |
| Dexamethasone | CANN 0.542, 0.098 | None |
| Dextromethorphan | PCP 0.565, 0.157 | OPI 250,000 ng/mL3,4 PCP 500,000 ng/mL2 25,000 ng/mL3 PROP 500,000 ng/mL3,4 |
| Digoxin | CANN 0.621, 0.071 | None |
| Escitalopram | PROP 0.534, 0.107 | TCA 200,000 ng/mL3,4 |
| 5-Fluorouracil | BARB 0.625, 0.220 | None |
| Fluoxetine | TCA 0.434, 0.288 | None |
| Gemfibrozil | CANN 0.604, 0.188 | None |
| Ipratropium | OPI 0.529, 0.105 | None |
| Maprotiline | TCA 0.659, 0.250 | TCA 10,000 ng/mL3 |
| Meprobamate | BARB 0.500, 0.190 | None |
| Mexiletine | AMPH 0.500, 0.286 | AMPH 20,000 ng/mL3 |
| Mirtazapine | TCA 0.653, 0.115 | TCA 500,000 ng/mL3,4 |
| Nifedipine | BARB 0.333, 0.090 | None |
| Norclozapine | BENZO 0.581, 0.179 PCP 0.519, 0.091 |
None |
| Oxcarbazepine | BARB 0.375, 0.067 | BARB 500,000 ng/mL2,4 |
| Phenytoin | BARB 0.542, 0.190 | None |
| Propylthiouracil | BARB 0.593, 0.312 | None |
| Quetiapine | TCA 0.485, 0.177 | TCA 100,000 ng/mL3 |
| Rapamycin | BARB 0.534, 0.073 | None |
| Reserpine | OPI 0.597, 0.108 | None |
| Rifampicin | OPI 0.587, 0.132 | None |
| Selegiline | AMPH 0.407, 0.333 MTD 0.556, 0.177 |
AMPH 40,000 ng/mL3,4 |
| Sibutramine | MTD 0.610, 0.231 | None |
| Simvastatin | CANN 0.604, 0.188 | None |
| Succinylcholine | PROP 0.549, 0.123 | None |
| Tamoxifen | MTD 0.578, 0.233 PROP 0.617, 0.235 |
None |
| Terbinafine | MTD 0.579, 0.156 | None |
| Thioridazine | PCP 0.490, 0.171 | TCA 100,000 ng/mL3 |
| Venlafaxine | PROP 0.696, 0.179 | None |
| Vinblastine | OPI 0.640, 0.133 | None |
| Warfarin | CANN 0.639, 0.198 | None |
1
Abbreviations and target compounds: AMPH, amphetamines (d-amphetamine); BARB, barbiturates (secobarbital); BENZO, benzodiazepines (diazepam); CANN, cannabinoids (9-carboxy-11-nor-Δ9-tetrahydrocannabinol); MTD, methadone; OPI, opiates (morphine); PCP, phencyclidine; PROP, propoxyphene; TCA, tricyclic antidepressants (desipramine)
2
Biosite Triage
3
Syva Emit
4
Previously unreported cross-reactive drug for a DOA/Tox screening immunoassay