Figure 6.

A model for the function of nuclear anchoring in the POP-1 regulation in mom-2 mutants. (a) When the nucleus is apart from the cell cortex, the Src activities at the cell cortex cannot facilitate POP-1 phosphorylation by LIT-1 kinase required for POP-1 nuclear export (Lo et al. 2004), resulting in the accumulation of nuclear POP-1. (b) When the nucleus is anchored to the cell cortex, the Src activities at the cell cortex facilitate POP-1 phosphorylation, resulting in lower nuclear POP-1 level. Nuclei and centrosomes are indicated by gray and blue circles, respectively.