Scheme 2.
Synthetic Route for hit series 2. Reagents and conditions: a) H2NNHMe, EtOH, 80°C, 1 h; b) ArCOH, EtOH, 80°C, 2 h; c) NaNO2, AcOH, 0→20°C, 16 h; d) DMF, 90°C, 2 h; e) R2Br, Cs2CO3, 80°C, 3 h, DMF.
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