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. 2010 Apr 12;207(4):855–865. doi: 10.1084/jem.20100244

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© 2010 Bothmer et al.

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Figure 4. — Resected DSBs are joined using microhomology-mediated end joining independently of 53BP1. (A) Bar graph shows microhomology at junctions of PCR products cloned from I-SceI–infected IgH^I-96kAID^−/− B cells. White bars indicate sequences with little resection (<30 nt), and black bars indicate sequences with resection ≥30 nt. A total of 67 individual sequences were analyzed from three different mice. (B) Bar graph shows microhomology at junctions of PCR products cloned from I-SceI–infected IgH^I-96kAID^−/−53BP1^−/− B cells. White bars indicate sequences with little resection (<30 nt), and black bars indicate sequences with resection ≥30 nt. A total of 48 individual sequences were analyzed from three different mice. (C) Table indicates the mean number of nucleotides of microhomology at junctions in I-SceI–infected IgH^I-96kAID^−/− and IgH^I-96kAID^−/−53BP1^−/− B cells.