Table II.
Assay for anti-phospholipid mAb inhibition of HIV-1 infectivity in a PBMC-based virus infection inhibition assay
| Primary HIV-1 isolates | mAbsa | |||||||||
| IS4 | CL1 | P1 | PGN632 | PGN401 | B1 | B2 | PGN635 | PGN634 | TriMabb | |
| µg/ml | µg/ml | µg/ml | µg/ml | µg/ml | µg/ml | µg/ml | µg/ml | µg/ml | µg/ml | |
| B.PVO | 0.34 | 0.21 | 4.5 | 0.03 | >50 | >50 | >50 | >50 | >50 | 0.64 |
| B.6535 | 0.07 | 0.38 | 4.0 | <0.02 | >50 | >50 | >50 | >50 | >50 | 2.4 |
| C.DU123 | 0.06 | 0.19 | <0.02 | <0.02 | 4.5 | >50 | >50 | 8.2 | >50 | >25 |
a
mAbs are shown as IC80 values (concentration of antibody resulting in 80% reduction of infection).
b
TriMab = equal concentration mixture of IgG1b12, 2F5, and 2G12.