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. 2010 May;69(5):425–426. doi: 10.1111/j.1365-2125.2010.03642.x

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Journal compilation © 2010 The British Pharmacological Society

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graphic file with name bcp0069-0425-fu1.jpg — Site of action of icatibant at the bradykinin-2 receptor. In hereditary angioedema (HAE) the C1 esterase inhibitor (C1INH) is deficient. This has consequences for the three metabolic pathways shown. Increased concentrations of bradykinin contribute to the major symptoms of HAE. Icatibant blocks the action of bradykinin and thus relieves the symptoms of vasodilatation, oedema, and pain. Abbreviations: B2: bradykinin-2 receptor; MAC: membrane attack complex; the roman numbers represents the different clotting factors. C1INH (); icatibant (□)

Inline graphic — Site of action of icatibant at the bradykinin-2 receptor. In hereditary angioedema (HAE) the C1 esterase inhibitor (C1INH) is deficient. This has consequences for the three metabolic pathways shown. Increased concentrations of bradykinin contribute to the major symptoms of HAE. Icatibant blocks the action of bradykinin and thus relieves the symptoms of vasodilatation, oedema, and pain. Abbreviations: B2: bradykinin-2 receptor; MAC: membrane attack complex; the roman numbers represents the different clotting factors. C1INH (); icatibant (□)