Table 7.
Model-derived pharmacokinetic parameter and other variables for total and unbound melphalan in 100 patients with multiple myeloma. Data are presented as median (interquartile range)
| Pharmacokinetic parameter/variable | Total melphalan | Unbound melphalan |
|---|---|---|
| CL (l h−1 kg−1) | 0.35 (0.28–0.43) | 1.59 (1.27–2.14) |
| CL (l h−1 m−2) | 14.4 (11.9–17.2) | 65.0 (51.3–88.0) |
| V1 (l kg−1) | 0.18 (0.14–0.21) | 0.79 (0.62–0.99) |
| V1 (l m−2) | 7.3 (5.6–9.0) | 32.2 (26.0–40.7) |
| k10 (h−1) | 1.95 (1.58–2.65) | 2.0 (1.8–2.4) |
| k12 (h−1) | 2.2 (1.8–2.9) | 2.4 (1.9–3.2) |
| k21 (h−1) | 2.0 (1.8–2.4) | 2.1 (2.0–2.3) |
 (h) |
0.13 (0.10–0.15) | 0.12 (0.10–0.13) |
 (h) |
0.97 (0.86–1.06) | 0.92 (0.84–1.05) |
| AUC (mg l−1 h) | 12.8 (10.8–15.1) | 2.80 (2.08–3.37) |
| Fraction unbound | 0.21 (0.17–0.27) |